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3 . 2021

Methodological approaches for the development of a digital clinical recommendation


This article provides an overview of the use of computer-interpreted clinical guidelines abroad, describes the benefits of using digital clinical guidelines in the healthcare system, and proposes a solution for translating clinical guidelines developed and used in the Russian Federation, into a machine-readable format.

Keywords:clinical practice guidelines, computer-interpretable guidelines, healthcare

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

Contribution. Concept development, idea formation, formulation of key goals and objectives - Engalychev D.N.; collection and analysis of materials, discussion of research results - Khodovskiy A.A., Levin M.B.

For citation: Engalychev D.N., Khodovskiy A.A., Levin M.B. Methodological approaches for the development of a digital clinical recommendation. ORGZDRAV: novosti, mneniya, obuchenie. Vestnik VSHOUZ [HEALTHCARE MANAGEMENT: News, Views, Education. Bulletin of VSHOUZ]. 2021; 7 (3): 70-81. DOI: (in Russian)


1. Overview of Russian medical decision support systems. URL: (date of access August, 2021) (in Russian)

2. Kuperman G.J., Gardner R.M., Pryor T.A. HELP: a Dynamic Hospital Information System, 1991.

3. Health Evaluation through Logical Processing (HELP). URL: (date of access August, 2021)

4. Isern D., Moreno A. Computer-based execution of clinical guidelines: a review. Int J Med Inform. 2008; 77 (12): 787-808. DOI:

5. Peleg M. Computer-interpretable clinical guidelines: a methodological review. J Biomed Inform. 2013; 46 (4): 744-63. DOI:

6. Bilici E., Despotou G., Arvanitis T. The use of computer-interpretable clinical guidelines to manage care complexities of patients with multimorbid conditions: a review. Digit Health. 2018; 4: 1-21. DOI:

7. Bilici Ozyigit E. MuCIGREF: Multiple Computer-Interpretable Guideline Representation and Execution Framework for Managing Multimorbidity Care, 2020.

8. Cyras K., et al. Assumption-based Argumentation with Preferences and Goals for Patient-Centric Reasoning with Interacting Clinical Guidelines. 1 Jan. 2021. P. 149189. DOI:

9. Zhang H., Ni W., Li J., Zhang J. Artificial Intelligence-Based Traditional Chinese Medicine Assistive Diagnostic System: Validation Study. JMIR Med Inform. 2020; 8 (6): e17608. DOI:

10. Binjie Cheng, Jin Zhang, Hong Liu, Meiling Cai, Ying Wang. Research on Medical Knowledge Graph for Stroke. J Healthc Eng. 2021; 2021: 5531327. DOI:

11. Wanheng Liu, Ling Yin, Cong Wang, Fulin Liu, Zhiyu Ni. Medical Knowledge Graph in Chinese Using Deep Semantic Mobile Computation Based on IoT and WoT. Wirel Commun Mob Comput. 2021; 2021: 5590754. DOI:

12. Leong T.Y., Kaiser K., Miksch S. Free and open source enabling technologies for patient-centric, guideline-based clinical decision support: a survey. In: Yearbook of Medical Informatics. 2007: 74-86. PMID: 17700908; PMCID: PMC2858818.

Guzel E. Ulumbekova
MD, MBA from Harvard University (Boston, USA), Head of the Graduate School of Healthcare Organization and Management (VSHOUZ), Associate Professor of the Department of Public Health and Health Care, Health Economics, Faculty of Pediatric of the Pirogov Russian National Research Medical University
Medicine today

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