To the content
2 . 2022

Review of international and Russian strategies for the diagnosis of iron deficiency


The occurrence of iron deficiency anemia in the world in 35% of women is urgent physicians in terms of recognizing nonspecific manifestations of iron deficiency conditions.

The aim is to determine the most optimal screening strategies for diagnosing latent iron deficiency and iron deficiency anemia based on the study of international experience.

Material and methods. The material of the study was international and domestic scientific articles on modern diagnostic practices of iron deficiency conditions (application in different countries of the approach set out in the European diagnostic algorithm, as well as laboratory diagnostic studies regulated by Russian clinical guidelines). Research methods – theoretical analysis and comparison of data obtained from literary sources.

Keywords:iron deficiency anemia; women; latent iron deficiency; serum ferritin

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

Contribution. The concept and design of the study – Shulaev A.V., Chernobrovkina G.I.; collection, processing of material, writing the text – Chernobrovkina G.I.; editing – Shulaev A.V.

For citation: Chernobrovkina G.I., Shulaev A.V. Review of international and Russian strategies for the diagnosis of iron deficiency. ORGZDRAV: novosti, mneniya, obuchenie. Vestnik VSHOUZ [HEALTHCARE MANAGEMENT: News, Views, Education. Bulletin of VSHOUZ]. 2022; 8 (2): 139–45. DOI: (in Russian)


1. Camaschella C. Iron-deficiency anemia. N Engl J Med. 2015; 372: 1832–43.

2. Vos T., Abajobir A.A., Abate K.H., Abbafati C., Abbas K.M., Abd-Allah F., et al. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017; 390: 1211–59. DOI:

3. Assessing the Iron Status of Populations. 2nd ed. [Electronic resource]. Geneva, Switzerland: World Health Organization, 2004. DOI: (date of assess January 30, 2022)

4. Beutler E., Waalen J. The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration? Blood. 2006; 107 (5): 1747–50.

5. Cook J.D., Boy E., Flowers C., Daroca M.C. The influence of high-altitude living on body iron. Blood. 2017; 106 (4): 1441–6.

6. WHO/NHD. Iron Deficiency Anaemia. Assesment, Prevention and Control: a guide for programme managers, 2001. URL:

7. Hercberg S., Preziosi P., Galan P. Iron deficiency in Europe. Public Health Nutr. 2001; 4: 537–45.

8. Borch-Iohnsen B., Sandstad B., Asberg A. Iron status among 3005 women aged 20–55 years in Central Norway: the Nord-Trondelag Health Study (the HUNT study). Scand J Clin Lab Invest. 2005; 65: 45–54.

9. Bermejo F., García-López S. A guide to diagnosis of iron deficiency and iron deficiency anemia in digestive diseases. World J Gastroenterol 2009; 15: 4638. DOI:

10. Volkova S.A., Mayansky N.A., Borovkov N.N., et al. Hemogram parameters in the adult working population. Gematologiya i transfuziologiya [Hematology and Transfusiology]. 2008; 53 (1): 21–7. (in Russian)

11. Drapkina O.M., Martynov A.I., Bayda A.P., Balan V.E., Baranov I.I., Vlasova E.E., et al. Resolution of the expert council «Actual issues of iron deficiency in the Russian Federation». Kardiovaskulyarnaya terapiya i profilaktika [Cardiovascular Therapy and Prevention]. 2020; 19 (5): 236–41. DOI: (in Russian)

12. Piperno A., Pelucchi S., Mariani R. Inherited iron overload disorders. Transl Gastroenterol Hepatol. 2020; 5: 25. DOI: PMID: 32258529; PMCID: PMC7063521.

13. Dignass A.U., Gasche C., Bettenworth D. et al.; European Crohn’s and Colitis Organisation [ECCO]. European consensus on the diagnosis and management of iron deficiency and anaemia in inflammatory bowel diseases. J Crohns Colitis. 2015; 9 (3): 211–22.

14. Gasche C., Berstad A., Befrits R., et al. Guidelines on the diagnosis and management of iron deficiency and anemia in inflammatory bowel diseases. Inflamm Bowel Dis. 2007; 13 (12): 1545–53.

15. McMurray J.J., Adamopoulos S., Anker S.D., et al.; ESC Committee for Practice Guidelines. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2012; 33 (14): 1787–847.

16. Baker R.D., Greer F.R.; The Committee on Nutrition. Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0–3 years of age). Pediatrics. 2010; 126: 1040–50.

17. Infusino I., Braga F., Dolci A., Panteghini M. Soluble transferrin receptor (sTfR) and sTfR/log ferritin index for the diagnosis of iron-deficiency anemia. A meta-analysis. Am J Clin Pathol. 2012; 138 (5): 642–9.

18. Spada C., Hassan C., Barbaro B., Iafrate F., Cesaro P., Petruzziello L., et al. Colon capsule versus CT colonography in patients with incomplete colonoscopy: a prospective, comparative trial. Gut. 2015; 64: 272–81. DOI: 306550

19. Oustamanolakis P., Koutroubakis I.E., Messaritakis I., Kefalogiannis G., Niniraki M., Kouroumalis E.A. Measurement of reticulocyte and red blood cell indices in the evaluation of anemia in inflammatory bowel disease. J Crohns Colitis. 2011; 5 (4): 295–300.

20. Musallam K.M., Tamim H.M., Richards T., et al. Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study. Lancet. 2011; 378: 1396–407.

21. Cappellini M.D., Musallam K.M., Taher A.T. Iron deficiency anaemia revisited. J Intern Med. 2020; 287 (2): 153–70. DOI:

Guzel E. Ulumbekova
MD, MBA from Harvard University (Boston, USA), Head of the Graduate School of Healthcare Organization and Management (VSHOUZ)
Medicine today

Съезд хирургов ФМБА России " Высокотехнологичная медицинская помощь: концепция безопасности и единого хирургического пространства " 14-15 октября 2022 года, г. Санкт-Петербург Впервые в истории хирургическая безопасность будет изучена столь подробно! Отныне "S afe surgery "...

Председатель организационного комитета 17-го Национального конгресса терапевтов - министр здравоохранения Российской Федерации - Михаил Альбертович Мурашко В программе конгресса запланированы более 150 образовательных секций, симпозиумов, клинических разборов, мастер-классов...

Уважаемые коллеги! Представляем оргкомитет 17-го Национального конгресса терапевтов (с международным участием) , который состоится 12-14 октября в МВЦ "Крокус Экспо" (павильон 3, Зал 20, г. Москва). · Президент Российского научного медицинского общества терапевтов,...

Journals of «GEOTAR-Media»